Depressive Symptoms are Frequent in Atypical Parkinsonian Disorders
نویسندگان
چکیده
منابع مشابه
Neuropathology of Atypical Parkinsonian Disorders
Although the clinical syndrome of parkinsonism (rigidity, bradykinesia, and tremor) is most often owing to idiopathic Parkinson’s disease (PD), it may also be associated with a variety of other underlying pathologies (Table 1) (1–3). Each of these other pathological conditions tends to have a characteristic clinical phenotype, however atypical cases are increasingly recognized (4–8). Moreover, ...
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Atypical parkinsonism encompasses several disorders that may have disease-specific or individualspecific characteristics, however common features include akinesia, rigidity, gait difficulties, and cognitive decline with gradual worsening of the symptoms. These features result in a variety of deficits that affect the patient’s ability to function in their usual capacity at home, on the job, and ...
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Parkinson’s disease (PD) is defined clinically as a disorder characterized by the presence of at least two of four cardinal signs, i.e., resting tremor, bradykinesia, rigidity, and postural instability, along with a good response to levodopa (1). Patients with typical PD do not manifest ataxia, chorea, orthostatic hypotension unrelated to medications, vertical downward-gaze deficits, amyotrophy...
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Studying archetypes is a fundamental task in nosography. Duchenne de Boulogne practiced it instinctively, and many others have done it before and after him: It is indispensable, and the only way to extract a specific pathological state from the chaos of imprecision. The history of medicine, which is long and grand, shows this truth well. But once the archetype is established, the second nosogra...
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Diagnosis of Parkinson' disease (PD) carries a high misdiagnosis rate due to failure to recognize atypical parkinsonian disorders (APD). Usually by the time of diagnosis greater than 60% of the neurons in the substantia nigra are dead. Therefore, early detection would be beneficial so that therapeutic intervention may be initiated early in the disease process. We used splice variant-specific mi...
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ژورنال
عنوان ژورنال: Movement Disorders Clinical Practice
سال: 2016
ISSN: 2330-1619
DOI: 10.1002/mdc3.12382